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. 2011 May 11;96(7):2154–2162. doi: 10.1210/jc.2010-2964

Fig. 5.

Fig. 5.

HLA-DR-DQ and HLA-B regions of conservation are noncontiguous (separated by polymorphic regions). A, SNPs across the MHC region. Each column represents a single DR4-B15 founder chromosome (n = 556) in the Type 1 Diabetes Genetics Consortium database of families with phased defined SNP haplotypes. Each row represents a SNP (n = 2828) with the allele in yellow if identical to the allele on the most common conserved DR401-B15 haplotype, in blue if the opposite allele, and in white if the allele could not be defined. The white column separates DRB1*0401 from DRB1*0404 T1DGC chromosomes. B, HLA genotype and sentinel SNP analysis in DR4-B15 chromosomes of 21OH-AA-positive nonprogressors. Alleles similar to the most common conserved DR404-B15 haplotype are seen in green, whereas alleles commonly on DR401-B15 haplotypes are in yellow. Orange represents non-401, non-404 haplotypes. Gene positions (indicated in parentheses in A) are based on National Center for Biotechnology Information Human Genome build 36.