Table 3.

Frequency of micronucleated polychromatic erythrocytes (MNPCEs) and nuclear division index (NDI) in peripheral blood of male Wistar rats submitted to acute, subacute and subchronic treatments with gels containing different concentrations of propolis and their respective controls.

Treatments (n = 5 rats/group)	Acute		Subacute		Subchronic
	MNPCEsa	NDIb	MNPCEsa	NDIb	MNPCEsa	NDIb
Control	0.24	0.18 ± 0.06	0.09	0.14 ± 0.03	0.10	0.12 ± 0.02
Without propolis	0.32	0.21 ± 0.08	0.08	0.14 ± 0.04	0.03	0.10 ± 0.03
1.2% Propolis	0.06	0.20 ± 0.05	0.09	0.16 ± 0.03	0.06	0.13 ± 0.02
2.4% Propolis	0.28	0.16 ± 0.04	0.15	0.17 ± 0.05	0.05	0.12 ± 0.03
3.6% Propolis	0.28	0.20 ± 0.03	0.15	0.13 ± 0.02	0.03	0.12 ± 0.02
CPAa	0.89	0.15 ± 0.03	0.89	0.15 ± 0.03	0.89	0.15 ± 0.03

A total of 2000 cells were analyzed per animal, for a total of 10 000 cells per treatment.

^aCPA, cyclophosphamide (50 mg/kg body weight), ^bValues are percentage, ^cValues are mean ± SD.