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. Author manuscript; available in PMC: 2011 Nov 5.
Published in final edited form as: Oncogene. 2011 Jan 10;30(18):2147–2160. doi: 10.1038/onc.2010.587

Figure 2.

Figure 2

Acute Vhl inactivation in hepatocytes is lethal. (A) PCR analysis of genomic DNA isolated from tissues of Vhl+/+ and VhlF/F animals at the indicated number of days post Ad-Cre injection; 1:1 mixture of genomic DNA containing unrecombined (VhlF) and completely recombined (VhlFrec) alleles was used as amplification control. (B) Western blot analysis of liver lysates from 24 hours fasted animals of the indicated genotypes following the stated number of days after Ad-Cre. (C) Survival curve of Ad-Cre injected animals of the indicated genotypes (n = 21).