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. Author manuscript; available in PMC: 2011 Jul 13.
Published in final edited form as: J Immunol. 2011 Jan 19;186(4):2273–2281. doi: 10.4049/jimmunol.1003601

Figure 5.

Figure 5

Functional blockade of Tregs in DSSKO mice leads to the development of arthritis. A, Arthritis development in mice injected i.v. with a mixture of anti-CD25 Abs or control rat Ig (black arrows) on days 5, 7, and 9 after zymosan treatment. Data represent the average arthritis score (±SEM) from three independent experiments for SKG and DSSKO mice. Data for WT and SLAP knockout mice are from one experiment. B and C, CFSE-labeled WT CD4+CD25− peripheral T cells were stimulated with anti-CD3 and anti-CD28 in the presence of the indicated ratios of either freshly isolated (B) or activated (C) CD4+CD25+ Tregs from WT, SLAP−/−, SKG, or DSSKO mice and proliferation determined by dilution of CFSE using flow cytometry. Data represent the average of three mice per genotype (±SEM) from three independent experiments.