Table 1.

Microarray gene expression profiling of MCF-7-sh-CCN5 and MCF-7-sh-scrambled cells

Gene symbol	Gene descriptiona	Fold change in MCF-sh-CCN5 expression relative to MCF7-sh-scrambled
Mesenchymal markers
CD44	CD44 molecule	+14.7
IGFBP7	Insulin-like growth factor binding protein 7	+8.5
ITGA5	Integrin α5	+5.1
LAMB3	Laminin beta 3	+37
LAMC2	Laminin gamma 2	+19.6
PROCR	Protein C receptor, endothelial	+8.2
SNAI2/SLUG	Snail homolog 2	+72.2
VIM	Vimentin	+188.3
ZEB1	Zinc finger E-box binding homeobox 1	+6.6
Epithelial markers
CD24	CD24 molecule	−20.4
CDH1	E-cadherin	−110.2
CLDN1	Claudin 1	−2
DSP	Desmoplakin	−3
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2	−4
ESR1	Estrogen receptor 1	−148
FOXA1	Forkhead box A1	−65
GATA3	GATA binding protein 3	−32
JUP	Junction plakoglobin	−25
KRT8	Keratin 8	−11
KRT18	Keratin 18	−6
MUC1	Mucin 1, cell surface associated	−5
TFF1	Trefoil factor 1	−427
TFF3	Trefoil factor 3	−2
XBP1	X-box binding protein 1	−12
TGF-β pathway markers
CTGF	Connective tissue growth factor	+12.1
FN1	Fibronectin 1	+8.9
JUN	v-jun sarcoma virus 17 oncogene homolog	+2.6
SERPINE1	Serpin peptidase inhibitor member 1	+116.3
SMAD1	SMAD, mothers against DPP homolog 1	−5.7
SMAD3	SMAD, mothers against DPP homolog 3	+2.1
SMAD6	SMAD, mothers against DPP homolog 6	−27.9
SPARC	Secreted protein acidic cysteine rich	+2
TGFBR1	TGF-β receptor 1	+3.2
TGFBR2	TGF-β receptor 2	+416.5
TGFBR3	TGF-β receptor 3	+44.6
TGFB1	TGF-β 1	+2.6
TGFB3	TGF-β 3	−37.6

^aDPP, decapentaplegic homologs.