Fig. 2.

Structure and DNA sequence preferences of TFII-I and proteins that interact with it. The gene for TFII-I contains six repeat regions, each encoding an HLH domain. In addition, an LZ motif, a nuclear localization sequence (NLS), a basic region (BR), and two Ph domains are located in the C terminus. TFII-I associates with USF and interacts with pyrimidine-rich initiator elements or E-box motifs. Proteins documented to interact with TFII-I are listed at the bottom (references are in brackets).