Fig. 3.

Structure and DNA sequence preferences of Tal1 and proteins that interact with it. Tal1 contains an HLH domain and a basic region (BR) in the CTD, as well as an activation domain (AD) and a nuclear localization sequence (NLS) in the N-terminal domain. The Tal1 gene contains a short upstream open reading frame (uORF). Tal1 associates with E proteins and binds to E-box elements, with a preference for the sequence CAGCTG. Tal1 also forms a large complex consisting of GATA-1, LMO2, and Ldb1 and binds to composite elements containing an E box and a GATA site separated by about 9 bp or to a GATA sequence only. The recruitment of Tal1 to CACCC motifs is likely mediated by proteins that have not been identified yet. Proteins documented to interact with Tal1 are listed at the bottom (references are in brackets).