Fig. 4.

Structure and DNA sequence preferences of Myc and proteins that interact with it. Myc contains a basic region (BR), an HLH domain, and an LZ in the CTD. Two Myc-binding elements (MB1 and MB2) and a nuclear localization sequence (NLS) are located in the N-terminal domain (NTD). Myc interacts with Max and binds to E-box motifs preferentially with CG, CA, TG, and CG residues in the center. It also interacts with genomic regions that lack E-box sequences; these associations are likely mediated by the interaction of Myc with other DNA-binding proteins. Proteins documented to interact with Myc are listed at the bottom (references are in brackets).