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Renal effects of celecoxib versus ibuprofen.
| Celecoxib 400 mg b.i.d. (N = 396) |
Ibuprofen 800 mg t.d.s. (N = 396) |
|
|---|---|---|
| Mean change in serum creatinine (mg/dL) | 0.009 ± 0.002 | 0.027 ± 0.004* |
| Mean change in estimated creatinine clearance (ml/min) | 0.08 ± 0.37 | −2.82 ± 0.51* |
b.i.d. twice a day; t.d.s. three times a day.
*P < .05 versus celecoxib by Fisher exact test.
