Table 3.
Epidemiologic and Clinicopathologic Characteristics of Patients With MCNs Compared With Those With Branch-Duct IPMNs
| MCNs (n = 168) | Branch-duct IPMNs (n = 159) | P value | |
|---|---|---|---|
| Median age, y (range) | 44.5 (16–82) | 66 (35–90) | .0001 |
| Sex (%) | |||
| Female | 160 (95) | 91 (57) | .0001 |
| Male | 8 (5) | 68 (43) | |
| Family history of pancreatic cancer (%) | |||
| Yes | 6 (3.5) | 16 (11) | .01 |
| No | 162 (96.5) | 126 (89) | |
| History of other neoplasm (%) | |||
| Yes | 15 (9) | 32 (20) | .006 |
| No | 153 (91) | 127 (80) | |
| Tumor site (%) | |||
| Proximal | 5 (3) | 82 (52) | .0001 |
| Distal | 163 (97) | 40 (25) | |
| Multifocal lesions | 0 | 37 (23) | |
| Incidental diagnosis (%) | |||
| Yes | 46 (27.5) | 55 (34.5) | .1 |
| No | 122 (72.5) | 104 (65.5) | |
| Abdominal pain (%)a | |||
| Yes | 104 (62) | 72 (45) | .004 |
| No | 64 (38) | 87 (55) | |
| Presence of other symptoms (%)a | |||
| Yes | 44 (26%) | 72 (45%) | .0001 |
| No | 124 (74%) | 87 (65%) | |
| Jaundice | 1 (0.5) | 7 (5) | .06 |
| Diabetes | 9 (5.5) | 14 (9) | .3 |
| Weight loss | 27 (16) | 37 (23) | .1 |
| Acute pancreatitis | 9 (5.5) | 27 (17) | .001 |
| Pathology (%) | |||
| Adenoma | 122 (73) | 71 (44) | .0001 |
| Borderline | 17 (10) | 54 (34) | .001 |
| Carcinoma in situ | 10 (6) | 17 (11) | .2 |
| Invasive carcinoma | 19 (11) | 17 (11) | .8 |
| Median tumor size, mm (range) | 49 (8–150) | 20 (5–100) | .0001 |
| Presence of lymph node metastases (%)b | 0 | 4 (23.5) | .08 |
a
Some patients complained of more than 1 symptom.
b
Rate of lymph node metastases was calculated considering only patients with invasive cancer.