Table I.

Pulmonary genes induced by i.t. IL-13 in IL-4Rα^−/−/SMP8–IL-4Rα^+/− mice

Gene	Alternate name	Description	Reference
Egln3	EGL nine homologue 3	A prolyl hydroxylase, involved in muscle differentiation, most highly expressed in muscle.	Fu et al., 2007
Vcan	Versican, chondroitin sulfate glycoprotein 2 (Cspg2)	A large chondroitin sulfate proteoglycan that is deposited in the airway smooth muscle layer in patients with asthma; promotes proliferation and migration of vascular smooth muscle cells.	Huang et al., 2006
Myocd	Myocardin	The dominant driver of smooth muscle differentiation and the smooth muscle contractile phenotype	Pipes et al., 2006
Rab39b	Ras-related protein Rab 39B	A member of the RAS oncogene family; small molecular weight GTPases that control vesicular trafficking. Ras family signaling is associated with differentiation, proliferation, and hypertrophy.	Sugden, 2003
Timp1	Tissue inhibitor of metalloproteinase 1	Expressed in dystrophic and regenerating muscle fibers, blocks extracellular matrix degradation.	Untergasser et al., 2005; Sun et al., 2006
Tnfrsf11b	TNF receptor superfamily, member 11b, osteoprotegerin (OPG)	Produced by smooth muscle cells; stimulates proliferation and migration of pulmonary artery smooth muscle cells in vitro.	Lawrie et al., 2008