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. 2011 Apr 11;208(4):653–661. doi: 10.1084/jem.20110105

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© 2011 Clappier et al.

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Figure 2. — Oncogenetic trees for the diagnosis, xenograft, and relapse T-ALL triads. The stepwise sequence of genomic events could be reconstructed from the DNA copy number and sequence data in the samples. XLE, unique identification numbers for the T-ALL cases; D, diagnosis; X, xenograft; R, relapse samples; R*, in the case of the triad XLE_61, limited genomic DNA at relapse allowed only to backtrack the PTEN lesions seen in the xenograft. Superscript letters indicate genomic alterations that involve different breakpoints or sequence mutation of the same locus or gene in the diagnosis, xenograft, and/or relapse samples from the same T-ALL case.