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. 2011 Jul 4;208(7):1351–1358. doi: 10.1084/jem.20100951

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© 2011 Naik et al.

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Figure 1. — GCV treatment reduces VEGF expression in B16.F1 tumors. (A) Western blot analysis of the expression of the two predominant isoforms of tumor-associated VEGF in homogenates of TK-expressing B16.F1 melanomas generated from tumors grown in WT mice treated with three daily injections of GCV and harvested on day 4. (B) VEGF ELISA performed on lysates from B16.F1 tumors treated as in A. Data represent mean ± SEM of five independent mice per genotype and treatment condition. (C) Representative photomicrographs of B16.F1 tumors treated as in A. Inset shows magnification of the boundary of VEGF-expressing and non-expressing tumor cells. Bar, 200 µm.