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. 2011 Jul 4;208(7):1501–1510. doi: 10.1084/jem.20110574

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© 2011 Daniel et al.

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Figure 4. — Dose response of insulin epitope and mimetope. (a) Cumulative diabetes incidence in NOD mice that were nonvaccinated, vaccinated with insulin B:9-23, or vaccinated by insulin mimetope 3 at 4–6 wk of age (doses 2.5–20 µg/d). n = 6 from two independent experiments. (b) In vivo T reg cell conversion using naive CD4⁺ insulin B:9-23 TCR transgenic T cells transferred into congenic NOD Thy1.1⁺ mice. Percentages of Foxp3⁺ T reg cells (± SEM, n = 6 from two independent experiments) at 2 wk after vaccination with indicated doses of peptide. *, P < 0.05; **, P < 0.01; ***, P < 0.001 versus insulin B:9-23.