Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jul 11;194(1):7–15. doi: 10.1083/jcb.201102095

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — Antioxidant proteins can regulate signaling pathways. Proteins like thioredoxin (Trx) can function in cells to maintain redox balance by catalyzing the reduction of oxidized proteins (top). Trx can in turn be reduced through a process involving thioredoxin reductase and NADPH. In addition, Trx can also participate in redox signaling by directly binding to signaling intermediates such as ASK1 (bottom). In this case, the Trx1–ASK1 interaction is redox dependent and in turn modulates the capacity of ASK1 to activate downstream effectors such as p38 MAPK and the c-Jun N-terminal kinase (JNK).