. Author manuscript; available in PMC: 2011 Jul 13.

Published in final edited form as: Nat Rev Rheumatol. 2010 Nov 9;6(12):683–692. doi: 10.1038/nrrheum.2010.176

Table 1.

SLE risk loci identified through GWAS in various ethnic groups

Study	Strong evidence (P<5×10^–8 Gene (OR))		Good evidence (P<10^–5) Gene (OR)
	Established^*	Novel^‡	Established^*	Novel^‡
European
Hom et al.⁴	HLA-DR3 (ND) IRF53 (ND) STAT4 (ND)	C8orf13-BLK (1.4) ITGAM-ITGAX (1.3)	NA	NA

Harley et al.⁵	HLA region (1.4–2.3) IRF5 (1.3–1.6) STAT4 (1.5)	ITGAM (1.3–1.7) PHRF1 (1.3) PXK (1.3) XKR6^§ (1.2–1.3) BLK (1.2) LYN (1.3)	PTPN22 (1.5) FCGR2A (1.4)	ATG5 (1.2) UBE2L3 (1.2) SCUBE1 (1.3)

Kozyrev et al.⁶	NA	BANK1 (1.4)	NA	NA

Graham et al.⁷	HLA region (ND) IRF53 (ND) STAT4 (1.5)	BLK (1.3) TNFAIP3 (2.3)	NA	ITGAM (ND)

Gateva et al.⁸^\|\|	HLA-DRB1 (2.0) IRF5 (1.9) STAT4 (1.6) PTPN22 (1.4) TNFSF4 (1.2) IL10 (1.2)	ITGAM (1.4) BLK (1.4) TNFAIP3 (1.7) PHRF1 (1.2) TNIP1 (1.3) PRDM1-ATG5 (1.2) JAZF1^§ (1.2) UHRF1BP1^§ (1.2)	IRAK1-MECP2(1.1)	UBE2L3 (1.2) ATG5 (1.2) PXK (1.2) IKZF1 (1.2) SLC15A4 (1.1)

*Asian*
Han et al.⁹	HLA region (1.9) IRF5 (1.4) STAT4 (1.5) TNFSF4(1.4–1.5)	BLK (1.3–1.4) PRDM1-ATG5 (1.3) TNFAIP3 (1.7) HIC-UBE2L3 (1.3) IKZF1^§ (1.4) RASGRP3^§ (1.4) SLC15A4^§ (1.3) TNIP1 (1.3) ETS1 (1.4) LRRC18-WDFY4 (1.2)	NA	NA

Yang et al.¹⁰	HLA region(1.8–2.0) STAT4 (1.7)	ETS1 (1.3) WDFY4 (1.3)	IRF5 (1.5)	TNFAIP3 (1.9) BLK (1.6)

Loci identified through candidate gene studies and GWAS.

^‡

Loci identified through GWAS only.

^§

Have not been replicated independently at the time of writing.

^||

Used a similar cohort to the Hom et al.⁴ study.

Abbreviations: GWAS, genome-wide association studies; NA, not applicable; ND, not determined; OR, odds ratio; SLE, systemic lupus erythematosus.