. Author manuscript; available in PMC: 2011 Jul 13.

Published in final edited form as: Nat Rev Rheumatol. 2010 Nov 9;6(12):683–692. doi: 10.1038/nrrheum.2010.176

Table 2.

SLE risk loci shared with other autoimmune diseases

Pathway	Gene	Location	Disease
*Lymphocyte regulation*
T-cell signaling	HLA class II	6p21.3	RA, SSc, Graves disease, IBD, T1D
	PTPN22^*	1p13	RA, T1D, SSc, Graves disease, Crohn’s disease
	TNFSF4	1q25	SSc

B-cell signaling	BANK1^*	4q24	SSc, RA
	BLK^*	8p23	SSc, pAPS
	Intergenic (PRDM1)	6q21	RA, Crohn’s disease
	Intergenic(IKZF1)	7p12	Crohn’s disease

*Innate immune regulation*
TLR–IFN signaling	IRF5	7q32	RA, IBD, SSc
TLR–IFN signaling	STAT4^*	2q33	RA, SS, SSc

TNF–NFκB signaling	TNFAIP3	6q23	RA, T1D, psoriasis, celiac disease
	TNIP1	5q33	Psoriasis

*Immune complex clearance*
Phagocytic	FCGR2A^*	1q23	T1D, UC

*Cytokine regulation*
Anti-in3ammatory	IL10^*	1q31–q32	UC, T1D

These loci were identified through GWAS, GWA meta-analysis studies, candidate gene studies or replication papers.

All genetic variants at the shared loci are common across the listed diseases.

Abbreviations: GWAS, genome-wide association studies; IBD, inflammatory bowel disease; IFN, interferon; NFκB, nuclear factor κB; pAPS, primary antiphospholipid syndrome; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, primary Sjögren’s syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; TLR, Toll-like receptor; TNF, tumor necrosis factor; UC, ulcerative colitis.