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. 2011 Jun 13;11:37. doi: 10.1186/1471-213X-11-37

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Copyright ©2011 Poulsen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Loss of S1P₁R inhibits cardiac growth and morphology at E10.5. E10.5 embryos were fixed, sectioned saggitally and stained with H&E. (A) S1P₁R+/+ hearts exhibits normal morphology. (B) S1P₁R-/- hearts demonstrate reduced myocardial tissue with a thin ventricular wall. (C) The average area of the myocardium at the level of the cardiac cushion, as well as the average area of the atrioventricular (AV) canal cushions and outflow tract (OFT) cushions, were determined. V = ventricle. S1P₁R+/+, N = 4; S1P₁R+/-, N = 5; S1P₁R-/-, N = 3, *P ≤ 0.02. Scale bar equals 500 μm.