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. 2011 Jun 13;11:37. doi: 10.1186/1471-213X-11-37

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Copyright ©2011 Poulsen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reduced fibronectin deposition observed in S1P₁R-/- hearts. E12.5 transverse embryo sections were immunostained with an anti-fibronectin antibody followed by a secondary antibody conjugated to Alexa Fluor 488 (green), and counterstained with propidium iodide (red). (A, B, C) S1P₁R+/+ hearts demonstrate strong FN staining in the outflow tract (OFT) and atrioventricular canal (AV) cardiac cushions, epicardial layer (arrow), and throughout the ventricular (V) myocardium and trabeculae (*). (D, E, F) FN expression in the epicardial layer (arrow) of S1P₁R-/- hearts revealed a more disorganized layer compared to S1P₁R+/+ hearts. In addition, the amount of FN deposited surrounding myocardial and trabecular cells was reduced compared to S1P₁R+/+ hearts. At = atrium. A, D scale bar = 200 μm; B, C, E, F scale bar = 100 μm.