Table 1.
Characteristics of HIV patients and population controls with lung cancer
| HIV patients N = 5053, |
HIV patients with lung cancer N = 29, |
Population controls with lung cancer N = 183, |
P value* | |
|---|---|---|---|---|
| N (%) | N (%) | N (%) | ||
| Male gender | 3827 (75.7) | 27 (93.1) | 156 (85.2) | 0.253 |
| Age at time of index date, median (IQR), years | 36.6 (30.4 - 44.3) | 49.9 (42.7 - 59.7) | 50.7 (45.1 - 59.5) | 0.554 |
| Age at time of cancer diagnosis, median (IQR), years | - | 57.0 (48.8 - 63.2) | 58.9 (52.2 - 67.5) | 0.192 |
| Native Danes | 3619 (71.6) | 24 (82.8) | 179 (97.8) | > 0.001 |
| Older than 50 years at index date | 695 (13.8) | 14 (58.3) | 98 (53.6) | 0.129 |
| Diagnosed with HIV before 1 January 1995 | 1968 (38.9) | 18 (62.1) | ||
| Smoker or former smoker in any quantity | 2600 (71.1) | 29 (100) | ||
| Route of HIV infection | ||||
| Men who have sex with men | 2287 (45.3) | 12 (41.4) | ||
| Heterosexually infected men | 934 (18.5) | 12 (41.4) | ||
| Heterosexually infected women | 930 (18.4) | 2 (6.9) | ||
| Injection drug user | 553 (10.9) | 3 (10.3) | ||
| Other | 349 (6.9) | 0 (0.0) | ||
| Baseline CD4 < 350 cells/μL or AIDS defining event at index date | 2655 (52.5) | 20 (69.0) | ||
| Baseline CD4 cell count, cells/μL, median (IQR) | 279 (104 - 480) | 230 (86 - 403) | ||
| Histological classification of lung cancer |
HIV patients with lung cancer N = 29 |
Population controls with lung cancer N = 183 |
P value | |
| Squamous cell carcinoma | 8 (27.6) | 36 (19.7) | ||
| Small cell carcinoma | 4 (13.8) | 31 (16.9) | ||
| Adenocarcinoma | 7 (24.1) | 55 (30.1) | ||
| Large cell carcinoma | 0 (0) | 12 (6.5) | ||
| Other and unclassified | 10 (34.5)** | 49 (26.8)*** | ||
| P value for difference in distribution of HPV site, potential HPV site and potentially unrelated HPV site | 0.457 | |||
*P value for differences in characteristics between HIV patients and population controls with lung cancer
**3 carcinoma without other specifications (M80103), 3 Non-Large cell carcinomas (M80463), 2 adenosquamos carcinomas (M85603), 1 no microscopically confirmed lung cancer (M99903) and 1 malignant histology unknown (M99993).
***2 neoplasm malignant (M80003), 3 malignant tumor cells (M80013), 3 carcinoma without other specifications (M80103), 22 Non-Large cell carcinomas (M80463), 3 carcinoid tumor, malignant (M82403), 1 neuroendocrine carcinoma (M82463), 1 adenosquamous carcinomas (M85603), 12 not microscopically confirmed lung cancer (M99903) and 2 malignant histology unknown (M99993).