Table 4.
Incidence rate ratios for lung cancer for the parent population stratified for the offspring's route of HIV infection
| Cancer, N | Unadjusted IRR (95% CI) | Adjusted IRR* (95% CI) | |
|---|---|---|---|
| All fathers of HIV patients** | 122/1233 | 1.38 (1.14 - 1.66) | 1.31 (1.09 - 1.58) |
| Stratification | |||
| Route of HIV infection for offspring | |||
| Men who have sex with men (MSM) | 65/535 | 1.34 (1.04 - 1.73) | 1.24 (0.96 - 1.61) |
| Heterosexually infected | 31/440 | 1.39 (0.97 - 2.00) | 1.31 (0.91 - 1.89) |
| Injection drug user (IDU) | 20/183 | 1.40 (0.89 - 2.23) | 1.63 (1.02 - 2.58) |
| All mothers of HIV infected*** | 78/763 | 1.37 (1.08 - 1.72) | 1.35 (1.07 - 1.70) |
| Stratification | |||
| Route of HIV infection for offspring | |||
| Men who have sex with men (MSM) | 41/342 | 1.29 (0.93 - 1.78) | 1.26 (0.90 - 1.73) |
| Heterosexually infected | 17/262 | 1.20 (0.73 - 1.96) | 1.20 (0.73 - 1.96) |
| Injection drug user (IDU) | 17/112 | 1.84 (1.10 - 3.06) | 2.01 (1.21 - 3.36) |
* Adjusted for age at parent index date (continuous variable) as well as year of birth of the parent divided into the following decades: - 1920, 1920-1930, 1930-1940, 1940-1950, 1950 - later.
** There were five cases of lung cancer among fathers of children who had other route of HIV infection and 85 among fathers of population controls.
*** There were one case of lung cancer among mothers of children who had other route of HIV infection