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. 2011 Jul 13;6(7):e22127. doi: 10.1371/journal.pone.0022127

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Zandt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In the left panel the membrane dynamics are shown that occur after the onset of OGD (solid line). The dashed and dotted lines show the progressive loss of ion gradients. When after a gradual rise the membrane potential reaches the excitation threshold, this subsequently results in spiking of the membrane voltage according to Eqns 1 and 2 (gray region, not resolved). The black line shows the average membrane potential during the spiking (averaged over 300 ms). After approximately 7 seconds of oscillations, the cell comes to rest again, with a resulting . The middle panel shows a close up of the start of spiking activity, the right panel shows the instantaneous firing rate.

Inline graphic — In the left panel the membrane dynamics are shown that occur after the onset of OGD (solid line). The dashed and dotted lines show the progressive loss of ion gradients. When after a gradual rise the membrane potential reaches the excitation threshold, this subsequently results in spiking of the membrane voltage according to Eqns 1 and 2 (gray region, not resolved). The black line shows the average membrane potential during the spiking (averaged over 300 ms). After approximately 7 seconds of oscillations, the cell comes to rest again, with a resulting . The middle panel shows a close up of the start of spiking activity, the right panel shows the instantaneous firing rate.