Table 5.
Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
---|---|---|---|---|
Anemia | 9 | 1 | - | - |
Lymphopenia | - | 1 | 1 | - |
Neutropenia | 1 | 2 | 2 | 1 |
Thrombocytopenia | 7 | - | - | - |
Fatigue | 4 | 6 | - | - |
Fever without neutropenia | 1 | - | - | - |
Rigors/chills | 1 | 1 | - | - |
Weight loss | 1 | 2 | - | - |
Alopecia | 6 | 1 | - | - |
Injection site reaction | 1 | - | - | - |
Rash/desquamation | 3 | 1 | - | - |
Anorexia | 2 | 2 | 2 | - |
Constipation | 4 | 1 | - | - |
Diarrhea without prior colostomy | 3 | 1 | 1 | - |
Dry mouth | 1 | - | - | - |
Gastritis | 1 | - | - | - |
Dyspepsia | 1 | - | - | - |
Stomatitis by exam | 3 | 1 | - | - |
Stomatitis (symptom) | 4 | 1 | - | - |
Nausea | 7 | 2 | - | - |
Obstruction, ileum | 1 | - | - | - |
Vomiting | 2 | 1 | - | - |
Stoma, upper respiratory hemorrhage | 1 | - | - | - |
Infection with grade 0–2 neutropenia, upper airway | - | 1 | - | - |
Edema, head and neck | 1 | - | - | - |
Elevated alkaline phosphatase | 3 | 1 | - | - |
Elevated ALT | 1 | - | 1 | - |
Elevated AST | - | - | - | 1 |
Elevated bilirubin | - | - | 1 | - |
Elevated gamma-glutamyl transferase | - | 1 | - | - |
Hypokalemia | 1 | - | - | - |
Hyponatremia | 2 | - | - | - |
Neuropathy, cranial nerve VII | 1 | - | - | - |
Neuropathy, cranial nerve XII | 1 | - | - | - |
Neuropathy-sensory | 3 | 1 | - | - |
Dry eye syndrome | 1 | - | - | - |
Vision-blurred | 1 | - | - | - |
Tearing | 1 | - | - | - |
Abdominal pain | 1 | - | 1 | - |
Chest pain | 1 | - | - | - |
Esophageal pain | 1 | - | - | - |
Facial pain | 1 | - | - | - |
Headache | 1 | - | - | - |
Joint pain | 1 | - | - | - |
Neck pain | 1 | - | - | - |
Oral cavity pain | 1 | - | - | - |
Pain, not otherwise specified | 1 | - | - | - |
Cough | 1 | - | - | - |
Dyspnea | 1 | - | - | - |
One patient is missing toxicity data in step 2