Table 5.
Grade 1–4 toxicities in patients treated with bortezomib plus doxorubicin (N=12†)
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Anemia | 9 | 1 | - | - |
| Lymphopenia | - | 1 | 1 | - |
| Neutropenia | 1 | 2 | 2 | 1 |
| Thrombocytopenia | 7 | - | - | - |
| Fatigue | 4 | 6 | - | - |
| Fever without neutropenia | 1 | - | - | - |
| Rigors/chills | 1 | 1 | - | - |
| Weight loss | 1 | 2 | - | - |
| Alopecia | 6 | 1 | - | - |
| Injection site reaction | 1 | - | - | - |
| Rash/desquamation | 3 | 1 | - | - |
| Anorexia | 2 | 2 | 2 | - |
| Constipation | 4 | 1 | - | - |
| Diarrhea without prior colostomy | 3 | 1 | 1 | - |
| Dry mouth | 1 | - | - | - |
| Gastritis | 1 | - | - | - |
| Dyspepsia | 1 | - | - | - |
| Stomatitis by exam | 3 | 1 | - | - |
| Stomatitis (symptom) | 4 | 1 | - | - |
| Nausea | 7 | 2 | - | - |
| Obstruction, ileum | 1 | - | - | - |
| Vomiting | 2 | 1 | - | - |
| Stoma, upper respiratory hemorrhage | 1 | - | - | - |
| Infection with grade 0–2 neutropenia, upper airway | - | 1 | - | - |
| Edema, head and neck | 1 | - | - | - |
| Elevated alkaline phosphatase | 3 | 1 | - | - |
| Elevated ALT | 1 | - | 1 | - |
| Elevated AST | - | - | - | 1 |
| Elevated bilirubin | - | - | 1 | - |
| Elevated gamma-glutamyl transferase | - | 1 | - | - |
| Hypokalemia | 1 | - | - | - |
| Hyponatremia | 2 | - | - | - |
| Neuropathy, cranial nerve VII | 1 | - | - | - |
| Neuropathy, cranial nerve XII | 1 | - | - | - |
| Neuropathy-sensory | 3 | 1 | - | - |
| Dry eye syndrome | 1 | - | - | - |
| Vision-blurred | 1 | - | - | - |
| Tearing | 1 | - | - | - |
| Abdominal pain | 1 | - | 1 | - |
| Chest pain | 1 | - | - | - |
| Esophageal pain | 1 | - | - | - |
| Facial pain | 1 | - | - | - |
| Headache | 1 | - | - | - |
| Joint pain | 1 | - | - | - |
| Neck pain | 1 | - | - | - |
| Oral cavity pain | 1 | - | - | - |
| Pain, not otherwise specified | 1 | - | - | - |
| Cough | 1 | - | - | - |
| Dyspnea | 1 | - | - | - |
†
One patient is missing toxicity data in step 2