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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2011 Feb 25;22(8):922–930. doi: 10.1111/j.1540-8167.2011.02032.x

Table 2.

Electrocardiographic parameters of the pups from nonimmunized and immunized Cav1.3 L-type Ca channel knockout mice

Immunized

Mothers (n)		 Pregnancy

(n)		 Deliveries

(n)		 Total

Pups(n)		 Genotype

(n)		 Bradycardia

n (%)		 Abnormality AVB (%)
I°AVB(n) 2°AVB(n) 3°AVB(n)
Cav1.3 KO c57BL/6 8 13 12 57 graphic file with name nihms268964t2.jpg 9(100) 8 1 0 100
    Nonimmunized 1(3.6) 1 0 0 3.6
0(0) 0 0 0 0
Cav1.3 KO c57BL/6 29 39 31 101 16(100) 9 graphic file with name nihms268964t3.jpg 100
    Immunized Hetero(n=52) 18(34.6) 16 5 1 42.3
NTG(n=33) 6(18) 5 1 0 18

n, number of animals; WT, wild type; KO, knockout. The AV block percentage was counted as 100% only when all pups had at least I°, II°, III° degree AV block. Highlighted Rectangle denotes advanced degrees of AV block Connection bar compares sinus bradycardia and AV block between KO pups from the nonimmunized and immunized Cav1.3 mothers.

*

Denotes statistical significance p<0.05.