Table 3.
Genotype Distribution and Association with Pancreatic Cancer Risk
SSTR5 Genotype | Cases n=863 (%) | Controls n=876 (%) | OR (95% CI)a | OR (95% CI)b | P valueb |
---|---|---|---|---|---|
P335L (rs4988487) | |||||
TT | 243 (28) | 267 (31) | 1.00 (reference) | 1.00 (reference) | |
CT | 434 (51) | 417 (49) | 1.15 (0.92–1.44) | 1.02 (0.75–1.39) | 0.902 |
CC | 176 (21) | 175 (20) | 1.08 (0.81–1.42) | 1.13 (0.88–1.46) | 0.332 |
L48M (rs4988483) | |||||
CC | 749 (90) | 764 (90) | 1.00 (reference) | 1.00 (reference) | |
AC | 87 (10) | 8 (10) | 0.99 (0.72–1.38) | 0.94 (0.66–1.34) | 0.739 |
P109S (rs169068) | |||||
CC | 764 (90) | 798 (92) | 1.00 (reference) | 1.00 (reference) | |
CT | 84 (10) | 65 (8) | 1.39 (0.98–1.97) | 1.62 (1.08–2.43) | 0.019 |
OR (95% CI) was adjusted for age, sex, family history of cancer, history of diabetes, and smoking.
OR was further adjusted for BMI.