Table 5.
Joint Effect of SSTR5 Genotype and Smoking on Pancreatic Cancer Risk
| Genotype | Smoking status | Cases/controls n/n | OR (95% CI)a | Pinteraction |
|---|---|---|---|---|
| P335L | 0.230 | |||
| TT | Never | 104/123 | 1.00 (reference) | |
| CC and CT | Never | 256/323 | 0.92 (0.65–1.31) | |
| TT | Ever | 139/144 | 1.34 (0.90–2.00) | |
| CC and CT | Ever | 356/269 | 1.71 (1.21–2.42) | |
| L48M | 0.035 | |||
| CC | Never | 319/385 | 1.00 (reference) | |
| AC | Never | 32/54 | 0.58 (0.34–0.97) | |
| CC | Ever | 430/379 | 1.49 (1.18–1.89) | |
| AC | Ever | 55/34 | 2.27 (1.35–3.83) | |
| P109S | 0.345 | |||
| CC | Never | 323/411 | 1.00 (reference) | |
| CT | Never | 34/36 | 1.34 (0.75–2.37) | |
| CC | Ever | 441/385 | 1.61 (1.28–2.03) | |
| CT | Ever | 50/28 | 3.17 (1.77–5.66) |
a
OR (95% CI) was adjusted for age, sex, family history of cancer, history of diabetes, and BMI.