Skip to main content
. Author manuscript; available in PMC: 2012 Jan 13.
Published in final edited form as: J Med Chem. 2010 Dec 6;54(1):366–373. doi: 10.1021/jm101230g

Table 1.

Physical Properties of N,N-dialkylindolylglyoxylamide Derivatives 17-31.

graphic file with name nihms-256999-t0001.jpg
17-31
Compd. R1 R2 R3 R4 R5 Yield (%) mp (°C) formulaα
17 Me Bn H H H 72 98-100 C24H20N2O2
18 Me Bn F H H 89 72-74 C24H19FN2O2
19 nPr nPr H Me H 90 110-112 C23H26N2O2
20 nBu nBu H Me H 79 83-85 C25H30N2O2
21 nHex nHex H Me H 90 oil C29H38N2O2
22 Et nBu H Me H 76 oil C23H26N2O2
23 Et Bn H Me H 70 oil C26H24N2O2
24 Me nBu H Me H 64 124-126 C22H24N2O2
25 Me nPen H Me H 70 126-128 C23H26N2O2
26 Me Bn H Me H 92 148-150 C25H22N2O2
27 nPr nPr H Me F 73 120-122 C23H25FN2O2
28 nPr nPr F Me H 83 132-134 C23H25FN2O2
29 nHex nHex F Me H 65 oil C29H37FN2O2
30 Me Bn F Me H 70 138-140 C25H21FN2O2
31 nPr nPr NO2 Me H 97 144-146 C23H25N3O4
α

Elemental analyses for C, H, N were within ± 0.4% of the calculated values.