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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Antiviral Res. 2011 Jun 2;91(2):177–186. doi: 10.1016/j.antiviral.2011.05.014

Figure 1. Polyamide binding sites within the HPV16 origin of replication (ori) and the structure of PA1.

Figure 1

(A) The minimal origin of replication (ori) of HPV16 genome is shown with the polyamide binding sites (PA-BS1-5, in bold) that were used in part to design a targeted polyamide library. The nucleotide 1/7904 boundary of the circular HPV16 genome is indicated. Numerous other binding sites for polyamides 1–24 exist within the HPV16 genome. (B) Structure of polyamide 1, selected for further study based upon its potent ability to decrease levels of HPV16 DNA episomes.