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Apparent IC50’s of polyamides 1 and 25 against 3 different high risk HPV episomes maintained in cells. The structures of the polyamides are represented by the following symbols: Im: Imidazole, P: Pyrrole, and β: beta-alanine.
| Polyamide 1 | Polyamide 25 | |
|---|---|---|
| ImPPβPPPγPPβPPPPβTa | ImPPβPPImβPPγPPβPPPβPPPβTa | |
| HPV16 | 0.100 ± 0.02 (n=4) | 0.036 ± 0.0004 (n=3) |
| HPV18 | 0.657 ± 0.16 (n=3) | 0.056 ± 0.01 (n=6) |
| HPV31 | 0.108 ± 0.02 (n=4) | 0.030 ± 0.001 (n=3) |
