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“Alcohol deprivation effect” resulted in upregulation of the CB1 receptor-mediated G-protein signaling in the striatum of sP rats, as shown by the comparison between alcohol-deprived (ADE) and -non deprived (Non-ADE) rat groups (25%, p<0.05; A). There was a significant reduction in the levels of AEA (17%, p<0.05; B) and 2-AG (20%, p<0.05; C) following “alcohol deprivation effect” in the striatum of sP rats, as shown by the comparison between alcohol-deprived and -non deprived rat.
