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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Addict Biol. 2011 Feb 11;17(1):62–75. doi: 10.1111/j.1369-1600.2010.00299.x

Figure 9.

Figure 9

Treatment with rimonabant (1 and 3 mg/kg, i.p.) significantly suppressed “alcohol deprivation effect” in alcohol-deprived sP rats and alcohol intake in alcohol-non deprived sP rats (*p<0.01 with respect to alcohol-non deprived rats receiving 0 mg/kg rimonabant; +p<0.01 with respect to alcohol-non deprived rats receiving 0 mg/kg rimonabant; @p<0.0005 with respect to alcohol-deprived rats receiving 0 mg/kg rimonabant; A). “Alcohol deprivation effect” was associated with a significant increase in CB1 receptor-mediated G-protein activation in the striatum (25%, *p<0.05 with respect to alcohol-non deprived rats; B). Treatment with rimonabant did not alter increased CB1 receptor-mediated G-protein activation associated to “alcohol deprivation effect” (B).