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. Author manuscript; available in PMC: 2012 Jul 20.
Published in final edited form as: J Am Chem Soc. 2011 Jun 23;133(28):10784–10786. doi: 10.1021/ja204277b

Scheme 2.

Scheme 2

Proline ligation with two Pro(SH) diastereomers.a

a Key: (a) 6 M Gn•HCl, 100 mM NaH2PO4, 50 mM TCEP, pH 7.5; (b) TCEP, VA-044, tBuSH, MeCN/H2O, 37 °C, 10 min, 88%. P1: ALLVNSS–; P2: –WEPLN; Ar = 2-(ethyldithio)phenyl.