Figure 2.

VPS35 Mutations and Cross-species Conservation

Protein orthologs were aligned via ClustalW. Amino acid positions for VPS35 p.Pro316Ser and p.Asp620Asn are highlighted in black. Protein orthologs with amino acid positions differing from those of the human sequence are indicated in gray. RefSeq accession numbers: Homo sapiens, NP_060676.2; Pan troglodytes, XP_001161439.1; Mus musculus, NP_075373.1; Rattus norvegicus, XP_214646.3; Bos taurus, NP_001039723.1; Canis familiaris, XP_532570.2; Gallus gallus, NP_001005842.1; Xenopus laevis, NP_001089981.1; Danio rerio, NP_001020688.2; Drosophila melanogaster, NP_726175.3; and Saccharomyces cerevisiae, NP_012381.1. An asterisk indicates that five aminoacids have been excluded from Drosophila melanogaster and Saccharomyces cerevisiae at this position.