Table 4.

Analysis of the Dallas Heart Study Sequencing Data

	SKAT	C	N	W	VTa	VTPa
Continuous TG level	9.5 × 10−5	1.9 × 10−3	7.2 × 10−5	2.3 × 10−4	3.5 × 10−4	2.0 × 10−5
Dichotomized TG level	1.3 × 10−4	3.2 × 10−2	2.2 × 10−3	3.1 × 10−3	8.6 × 10−3	2.1 × 10−3

Analysis of the Dallas Heart Study sequencing data with SKAT, the weighted sum burden test (W), the counting-based burden test (N), the CAST method (C), the varying-threshold method (VT), and the Polyphen-score adjusted VT (VTP) method. Beta (1, 25) is used as the weight in the SKAT and the weighted sum test.

^ap values are estimated on the basis of 10⁶ permutations.