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. 2011 Jul 11;2:32. doi: 10.3389/fphys.2011.00032

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Copyright © 2011 Campbell, Zhang, Haley, Liu, Loughran, Schell, Albert and Thakar.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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The response of site IV-specific T_CD8s is shown in case of (A) clearance, (B) non-zero steady state, (C) oscillations, (D) tumor, and (E) uncontrolled response of Tag-expressing cells (Tag-expressing cells shown in insets). In all cases the initial condition is Tag-expressing cells = 100, site IV-specific T_CD8 = 0. The parameters r = 0.03/day, n = 1.8 (proportion), b = 0.5/day, c = 0.5/day, w = 0.2/day, α = 40 cells, β = σ = 10 cells are used in all figures with the following exceptions: (A) n = 0.3 (proportion), c = 0.29/day; (B) β = σ = 50/day; (C) β = σ = 100/day; (D) c = 0.15/day; (E) c = 0.21/day.