Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury

. 2011 Jun 1;2011:891605. doi: 10.1155/2011/891605

(a)

Time after contusion	Group 1: laminectomy N = 5	Group 2: contusion N = 7	Group 3: contusion + hNT2-6 N = 6	Group 4: contusion + hNT2-19 N = 7	Group 5: laminectomy + hNT-19 N = 5	Group 6: laminectomy + hNT2-6 N = 7	One way ANOVA
	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	F-statistic, P value

Baseline	34.2 (0.13)^a	34.8 (0.24)^b	34.8 (0.1)^c	34.8 (0.23)^d	34.6 (0.16)^e	34.7 (0.28)^f	1.03, P = .417
7	34.0 (0.51)^a	17.8 (1.45)^b	NA	NA	NA	NA	81.9, P < .000
14 (10)*	34.5 (0.26)^a	16.8 (1.52)^b	17.3 (0.81)^c	17.6 (0.62)^d	34.8 (0.17)^e	35.4 (0.39)^f	175.9, P < .000
21	34.5 (0.28)^a	15.9 (0.86)^b	18.1 (0.91)^c	27.2 (0.98)^d	34.2 (0.18)^e	34.5 (0.29)^f	139.2, P < .000
28	34.5 (0.15)^a	16.4 (0.74)^b	16.8 (0.61)^c	28.4 (0.60)^d	34.0 (0.28)^e	34.4 (0.27)^f	264.4, P < .000
35	34.9 (0.14)^a	16.6 (0.79)^b	17.2 (0.63)^c	29.8 (0.48)^d	34.1 (0.10)^e	35.0 (0.14)^f	302.5, P < .000
42	34.4 (0.17)^a	16.7 (0.56)^b	16.8 (0.80)^c	31.0 (0.59)^d	34.7 (0.44)^e	34.8 (0.28)^f	282.0, P < .000
49	34.8 (0.28)^a	17.0 (0.64)^b	17.2 (1.09)^c	31.1 (0.25)^d	33.4 (0.40)^e	33.7 (0.27)^f	217.2, P < .000
56	34.9 (0.11)^a	17.0 (0.50)^b	16.7 (0.99)^c	32.2 (0.47)^d	34.0 (0.14)^e	34.1 (0.26)^f	291.8, P < .000

*Time after contusion t14 is 10 days for groups 2, 3, 4 and 14 days for 1, 6, and 7.

Post hoc analyses (Bonferroni):

^aGroup 1 is significantly different than Groups 2, 3, 4 on all time points.

^bGroup 2 is significantly different than Groups 1, 4, 5, 6 at all time points except for t14 when it is not significantly different from group 4.

^cGroup 3 is significantly different than Groups 1, 4, 5, 6 at all time points except for t14 when it is not significantly different from group 4.

^dGroup 4 is significantly different from all groups on times 21, 28, 35, 42; t14: significantly different from groups 1, 5, 6; t49: all but group 5; t6: all but 5 and 6.

^eGroup 5 is significantly different from groups 2, 3, 4 on all time points except at t49 and t56 where group 5 is significantly different only from groups 2 and 3.

^fGroup 6 is significantly different from groups 2, 3, 4 on all time points except at t56 where group 5 is significantly different from 2 and 3 only.