Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury

. 2011 Jun 1;2011:891605. doi: 10.1155/2011/891605

(a)

Time after contusion	Group 1: laminectomy N = 5	Group 2: contusion N = 7*	Group 3: contusion + hNT2-6 N = 6*	Group 4: contusion + hNT2-19 N = 7*	Group 5: laminectomy + hNT-19 N = 5	Group 6: laminectomy + hNT2-6 N = 7	One way ANOVA
	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	Mean (SEM)	F-statistic, P value
Baseline	14.6 (0.09)	14.7 (0.14)	14.5 (0.18)	14.5 (0.10)	14.3 (0.12)	14.2 (0.17)	1.46, P = .230 (ns)
7	14.2 (0.17)^a	7.11 (0.21)^b	NA	NA	NA	NA	607.0, P < .000
14 (10)*	14.2 (0.26)^a	6.53 (0.41)^b	8.17 (0.26)^c	7.84 (0.45)^d	14.5 (0.12)^e	14.4 (0.17)^f	144.3, P < .000
21	14.0 (0.11)^a	7.63 (0.31)^b	8.46 (0.27)^c	11.4 (0.39)^d	14.7 (0.10)^e	14.5 (0.15)^f	137.3, P < .000
28	13.9 (0.13)^a	7.36 (0.18)^b	7.80 (0.39)^c	12.2 (0.26)^d	14.2 (0.11)^e	14.2 (0.18)^f	184.3, P < .000
35	14.3 (0.12)^a	7.54 (0.08)^b	8.02 (0.38)^c	12.3 (0.28)^d	14.6 (0.16)^e	14.4 (0.09)^f	232.5, P < .000
42	14.2 (0.10)^a	7.26 (0.08)^b	7.73 (0.35)^c	13.3 (0.40)^d	14.1 (0.30)^e	14.4 (0.10)^f	173.8, P < .000
49	14.5 (0.20)^a	7.56 (0.14)^b	7.89 (0.42)^c	12.8 (0.29)^d	14.4 (0.16)^e	14.6 (0.12)^f	189.1, P < .000
56	14.8 (0.11)^a	7.50 (0.12)^b	7.76 (0.49)^c	13.2 (0.49)^d	14.6 (0.10)^e	14.6 (0.18)^f	120.7, P < .000

*Time after contusion t14 is 10 days for groups 2, 3, 4 and 14 days for 1, 6, and 7.

Post hoc analyses (Bonferroni):

^aGroup 1 is significantly different than Groups 2, 3, 4 at all time points except for t42 when it is not significantly different from group 4.

^bGroup 2 is significantly different than Groups 1, 4, 5, 6 at all time points except for t14 when it is not significantly different from group 4 but from group 3.

^cGroup 3 is significantly different than Groups 1, 4, 5, 6 at all time points except for t14 when it is not significantly different from group 4 but from group 3.

^dGroup 4 is significantly different from all groups on times 21, 28, 35, 49; t14: significantly different from groups 1, 5, 6; t42: significantly different from groups 23; t56: all but 5 and 6.

^eGroup 5 is significantly different from groups 2, 3, 4 on all time points except at t42 and t56, where group 5 is significantly different only from groups 2 and 3.

^fGroup 6 is significantly different from groups 2, 3, 4 on all time points except at t42 and t56 where group 6 is significantly different from groups 2 and 3 only.