Table 2.

Native Platelet Aggregation and Activation Measures by the Presence of the Metabolic Syndrome and its Components in the Sample Population (n = 2088)

	Measures of platelet aggregation or activation
	Collagen (Ω)	ADP (Ω)	Arachidonic acid (Ω)	TxMa(ng/mmol creatinine)
	Median and interquartile range
Metabolic syndrome present	20 (16–24)	13 (10–16)	16 (12–21)	155 (97–241)
Metabolic syndrome absent	19 (16–23)	12 (9–16)	15 (12–20)	137 (83–235)
P valueb	0.002	<0.001	<0.001	0.004
Number of components	Average percentile rank
0 (n = 467)	47.6%ile	47.5%ile	44.9%ile	46.2%ile
1 (n = 525)	46.5%ile	47.8%ile	47.8%ile	49.4%ile
2 (n = 506)	50.3%ile	51.1%ile	51.7%ile	50.7%ile
3 (n = 349)	54.4%ile	53.1%ile	54.1%ile	52.9%ile
4 (n = 189)	55.1%ile	53.1%ile	56.1%ile	52.3%ile
5 (n = 53)	57.0%ile	52.8%ile	53.4%ile	55.8%ile
Trend in ranks P valuec	<0.001	<0.001	<0.001	<0.001

Whole blood aggregation measures: Aggregation responses in electrical impedence units in response to the agonists 1 μg/mL collagen, 10 μM ADP, 0.5 mM arachidonic acid.

^an = 1953

^bWilcoxon rank sum test.

^cKusick nonparametric trend test.

Abbreviations: ADP, adenosine diphosphate; TxM, 11-dehydrothromboxane B2.