Table 3.

Standardized Adjusted Platelet Activation and Aggregation Measures in the Native State by Metabolic Syndrome Presence

Platelet activation measure	Metabolic syndrome present	Metabolic syndrome absent	P value (model 1) n = 2082	P value (model 2) n = 2002	P value (model 3) n = 1822
Collagen (Ω)	20.4 ± 0.3	19.0 ± 0.2	<0.001	<0.001	<0.001
ADP (Ω)	13.0 ± 0.2	12.2 ± 0.2	0.003	0.024	0.020
Arachidonic acid (Ω)	16.7 ± 0.3	15.3 ± 0.2	<0.001	<0.001	0.002
TxM (ng/mmol creatinine)a	148.0 (134.4–162.9)	131.2 (122.7–140.3)	0.042	0.019	0.095

Whole blood aggregation measures: Aggregation responses in electrical impedence units in response to the agonists collagen, 1 μg/mL collagen; ADP, 10 μM ADP; arachidonic acid, 0.5 mM arachidonic acid. Fibrinogen and hs-CRP were log-transformed prior to inclusion as covariates.

TxM indicated urinary excretion of thromboxane metabolite 11-dehydro thromboxane B2, a measure of in vivo platelet activation. All platelet measures are presented standardized for the average of the study sample 44 years of age, 58% women, 123 mg/dL of LDL, 25% smokers, 40% black, 0.5% other race (model 1), further adjustment for fibrinogen (model 2) and hs-CRP (model 3).

^aPresented as the geometric mean and its 95% confidence interval (model 1, n = 1953; model 2, n = 1877; model 3, n = 1706).

Abbreviations: ADP, adenosine diphosphate; TxM, 11-dehydrothromboxane B2.