Table 4.
Significance Levelsa (P Values) for the Independent Association of Each Component of the Metabolic Syndrome With Measures of Native Platelet Activity Prior to Aspirin (n = 2082)
| Collagen (Ω) | ADP (Ω) | Arachidonic acid (Ω) | TxM (ng/mmol creatinine) (n = 1951) | |
|---|---|---|---|---|
| Waist circumference | 0.066 | 0.297 | 0.005 | 0.060 |
| Low HDL-C | 0.027 | 0.064 | <0.001 | 0.416 |
| High triglycerides | 0.010 | 0.028 | 0.075 | 0.047 |
| IFG/diabetes | 0.040 | 0.426 | 0.182 | 0.525 |
| Pre/hypertension | <0.001 | 0.597 | 0.003 | 0.881 |
Whole blood aggregation measures: Aggregation responses in electrical impedence units in response to the agonists 1 μg/mL collagen, 10 μM ADP, 0.5 mM arachidonic acid.
a
All associations are adjusted for all other metabolic components, age, sex, race, LDL-C levels, and current smoking.
Abbreviations: ADP, adenosine diphosphate; HDL-C, high-density lipoprotein cholesterol; IFG, impaired fasting glucose >100mg/dL.