Table 5.
Post-Aspirin Platelet Aggregation and Activation Measures by the Presence of the Metabolic Syndrome and its Components in the Sample Population (n = 2007)
| |
Measures of platelet aggregation or activation |
|||
|---|---|---|---|---|
| Collagen (Ω) | ADP (Ω) | Arachidonic acid (Ω) | TxM (ng/mmol creatinine) | |
| Median (interquartile range) | ||||
| Metabolic syndrome present | 5 (2–9) | 13 (9–16) | 0 (0–0) (8% non-zero) | 36 (24–59) |
| Metabolic syndrome absent | 5 (2–9) | 12 (8–16) | 0 (0–0) (6% non-zero) | 32 (20–51) |
| P valuea | 0.076 | 0.002 | 0.116 | <0.001 |
| By number of components | Average percentile rank | |||
| 0 (n = 451) | 48.4 | 46.3 | 48.6 | 46.3 |
| 1 (n = 511) | 48.9 | 48.2 | 49.5 | 46.7 |
| 2 (n = 500) | 50.5 | 51.7 | 51.1 | 51.5 |
| 3 (n = 342) | 51.6 | 53.9 | 50.4 | 54.6 |
| 4 (n = 187) | 52.7 | 53.1 | 51.2 | 53.1 |
| 5 (n = 50) | 49.8 | 49.2 | 50.8 | 59.7 |
| Trend in ranks P valueb | 0.046 | <0.001 | 0.003 | <0.001 |
Whole blood aggregation measures: Aggregation responses in electrical impedence units in response to the agonists 1 μg/mL collagen, 10 μM ADP, 0.5 mM arachidonic acid.
a
Wilcoxon rank sum test.
b
Kusick nonparametric trend test.
Abbreviations: ADP, adensoine diphosphate; TxM, 11-dehydrothromboxane B2.