Fig. 5.

Replication and clearance of SV from the brains of CXCL13^−/− mice is similar when compared to CXCL13^+/+ controls. Brain tissue was collected from SV-infected animals and tissue viral titers were measured by plaque titration assays as described in Section 2. Both peak titer and the rate of viral clearance are unaltered by the loss of CXCL13 (curves are not significantly different from each other as measured by two-way ANOVA, although both groups changed significantly over time). All values represent the mean ± SEM of titers measured from at least triplicate samples.