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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Circ Res. 2011 May 5;109(1):80–85. doi: 10.1161/CIRCRESAHA.110.237594

Figure 2. Panx is involved in PE constriction of TDA.

Figure 2

The effect of cumulative concentrations of PE on internal diameter of pressurized TDA was significantly decreased after treatment with Panx inhibitors: (A) mefloquine (10 μmol/L), (B) 10Panx1 peptide (200 μmol/L) and (C) probenecid (2 mmol/L and 500μmol/L). (D), effect of apyrase (1 U/mL and 10 U/mL). We also inhibited purinergic receptors with suramin (100 μmol/L and 300 μmol/L), (E) and P2Y receptors with RB-2 (75 μmol/L); (F). n indicates the number of vessels and the value in parentheses is the number of mice. *P<0.05.