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. 2011 May 25;2011:827565. doi: 10.1155/2011/827565

Table 2.

Relative expression of the examined genes.

Gene Normals Chronic HBV hepatitis Chronic HCV hepatitis NAFLDb Autoimmune diseasesc MTX-related toxicityd
(no. 8) Diagnosis
(no. 19)
Relapse
(no. 7)
(no. 14) (no. 11) (no. 8) (no. 2)
Mean ± S.D. Mean ± S.D.
(P valuea)
Mean ± S.D.
(P valuea)
Mean ± S.D.
(P valuea)
Mean ± S.D.
(P valuea)
Mean ± S.D.
(P valuea)
Mean ± S.D.

Foxp3 1.11 ± 0.71 20.3 ± 16.0 (<.001) 10.4 ± 5.47 (.001) 12.7 ± 12.3 (.001) 18.4 ± 11.9 <.001 16.0 ± 15.2 (.001) 28.4 ± 27.8
TGF-β 1 1.56 ± 1.49 1.10 ± 0.84 (.710) 0.53 ± 0.31 (.053) 0.73 ± 0.58 (.065) 1.60 ± 1.01 (.620) 1.43 ± 1.04 (.834) 0.72 ± 0.17
IL-10 1.50 ± 1.02 0.66 ± 1.33 (.011) 0.20 ± 0.24 (.016) 0.48 ± 0.77 (.017) 0.79 ± 0.77 (.131) 0.64 ± 0.94 (.093) 0.59 ± 0.62
Fas 0.82 ± 0.24 2.25 ± 0.70 (<.001) 2.12 ± 0.78 (.003) 1.55 ± 1.07 (.179) 3.51 ± 1.17 (<.001) 1.56 ± 0.94 (.132) 4.14 ± 0.41
FasL 1.05 ± 1.47 4.20 ± 2.05 (.001) 3.05 ± 1.98 (.028) 4.20 ± 4.09 (.004) 3.94 ± 4.42 (.004) 4.33 ± 3.69 (.008) 0.49 ± 0.39
TRAIL 2.89 ± 2.04 7.28 ± 4.34 (.007) 11.3 ± 6.29 (.015) 8.86 ± 4.56 (.001) 15.3 ± 6.64 (<.001) 3.52 ± 2.11 (.355) 15.3 ± 12.7
Caspase-3 1.87 ± 1.85 1.13 ± 0.74 (.915) 0.76 ± 0.43 (.366) 1.66 ± 1.34 (.700) 1.97 ± 1.05 (.283) 3.19 ± 2.23 (.093) 2.28 ± 0.66
TNF-α 3.43 ± 4.70 1.77 ± 3.12 (.307) 1.54 ± 1.93 (.201) 2.73 ± 3.58 (.544) 8.17 ± 11.0 (.480) 6.63 ± 9.11 (.186) 1.21 ± 0.93
IFN-γ 1.92 ± 1.77 5.47 ± 5.99 (.202) 4.17 ± 2.46 (.186) 2.19 ± 1.77 (.628) 4.18 ± 4.93 (.572) 8.43 ± 7.25 (.059) 0.37 ± 0.26
IL-1β 1.37 ± 1.05 0.51 ± 1.39 (.022) 0.41 ± 0.66 (.055) 0.33 ± 0.26 (.042) 0.99 ± 0.95 (.322) 1.15 ± 1.12 (.571) 0.30 ± 0.23

aStatistical significance refers to comparison with the expression levels in the normal controls (Mann-Whitney U test); bNAFLD: nonalcoholic fatty liver disease; cautoimmune diseases group consists of 4 patients with autoimmune hepatitis and 4 with primary biliary cirrhosis; dMTX: methotrexate.