Table 1.

Effects of synaptic blockers on physiological properties of ON, OFF T, and OFF S RGCs

	Vm ctrl (mV)	Vm block (mV)	Rn ctrl (MΩ)	Rn block (MΩ)	Rate ctrl (Hz)	Rate block (Hz)	CV ctrl (SD/mean)	CV block (SD/mean)
ON	−54.8 ± 2.7	−65.5 ± 1.3	57.6 ± 2.6	57.3 ± 6.3	14.0 ± 3.5		0.61 ± 0.05
OFF T	−60.3 ± 2.7	−54.6 ± 1.0	58.6 ± 7.3	67.5 ± 6.6	14.3 ± 5.5	20.3 ± 3.0	0.54 ± 0.10	0.27 ± 0.03
OFF S	−60.2 ± 2.1	−55.1 ± 1.1	60.5 ± 6.7	117.1 ± 15.9	16.6 ± 5.4	43.3 ± 3.5	0.33 ± 0.04	0.14 ± 0.01
n	6, 7, 4	9, 7, 11	5, 7, 6	5, 6, 9	9, 7, 5	9, 8, 10	9, 5, 5	9, 8, 10
t test
ON-OFF T	NS	**	NS	NS	NS		NS
ON-OFF S	NS	**	NS	*	NS		**
OFF T-OFF S	NS	NS	NS	*	NS	**	NS	**

Shown are changes in measured V_m, input resistance (R_n), mean firing rate, and CV of interspike intervals for each cell type. ctrl, Control.

*p < 0.05,

**p < 0.01; NS, p ≥ 0.05. Data are mean ± SEM. For explanation of measurements, see Materials and Methods.