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. Author manuscript; available in PMC: 2011 Jul 14.
Published in final edited form as: Mol Cell Neurosci. 2006 Nov 20;34(1):59–68. doi: 10.1016/j.mcn.2006.10.003

Figure 3. Induction of neural progenitors by incubation of MSCs with trophic factors.

Figure 3

A. Precursor cells incubated in NT3, FGF and BDNF that support neuronal and sensory cell progenitors in the inner ear were seen by RT-PCR to have gene profiles that included expression of Oct4, nestin, Otx2, and Musashi, as well as proneural transcription factors, GATA3, NeuroD, Ngn1, Math1, Brn3c, and Zic2. These cells did not express hair cells genes, myosin VIIa and espin. B. In the cells obtained after induction with NT3, FGF, and BDNF, genes characteristic of supporting cells (claudin14, connexin 26, p75Trk, Notch 1, and S100A) were also observed. These progenitor cells thus had expression profiles characteristic of neuronal or sensory progenitors. Genes analyzed are shown to the left of the gels.