Table 5. Effect of H+-V-ATPase inhibitors on the sidedness of the expression of Spaw, a left-side marker in zebrafish.
| Expression | Left | Right | Bilateral | None | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Treatment | n | % | n | % | n | % | n | % | χ2 | P |
| Spaw | Control | 25 | 93% | 1 | 4% | 1 | 4% | 0 | 0% | ||
| A16 | 17 | 45% | 9 | 24% | 12 | 32% | 0 | 0% | 13.787 | ≪0.001 | |
| Control | 22 | 92% | 1 | 4% | 1 | 4% | 0 | 0% | |||
| Concanamycin | 11 | 42% | 9 | 35% | 6 | 23% | 0 | 0% | 11.439 | ≪0.001 | |
The laterality Spaw expression is significantly altered in zebrafish larvae treated with the H+-V-ATPase inhibitors lobatomide A16 or concanamycin.