Table 2.
UCP1 sequence variations and their frequencies in obese and control subjects.
| Polymorphisms | Obese patients | Control subjects | |||||
|---|---|---|---|---|---|---|---|
| n = 100 | n = 100 | ||||||
| Position | rs# | wt | HE | HO | wt | HE | HO |
| g.−637T>C1 | 99 | 1 | 0 | 100 | 0 | 0 | |
| g.−451C>T | rs36207410 | 82 | 16 | 2 | 86 | 14 | 0 |
| g.−412A>C | rs3811787 | 57 | 36 | 7 | 49 | 43 | 8 |
| g.−372A>C | rs1800660 | 97 | 3 | 0 | 97 | 3 | 0 |
| g.−206C>A1 | 99 | 1 | 0 | 100 | 0 | 0 | |
| g.−56C>T | rs3749539 | 91 | 9 | 0 | 90 | 10 | 0 |
| g.−17C>G1 | 94 | 6 | 0 | 94 | 6 | 0 | |
| g.12A>C | rs10011540 | 91 | 9 | 0 | 90 | 10 | 0 |
| g.21G>A | rs1800661 | 86 | 13 | 1 | 79 | 21 | 0 |
| g.940G>A (p.A64T) | rs45539933 | 92 | 8 | 0 | 91 | 9 | 0 |
| g.IVS2+138C>T | rs7688743 | 80 | 15 | 5 | 70 | 27 | 3 |
| g.IVS2+174T>A1 | 99 | 1 | 0 | 100 | 0 | 0 | |
| g.IVS2+201T>G | rs2071416 | 79 | 21 | 0 | 77 | 22 | 1 |
| g.IVS4−208T>G2 | rs1494808 | 45 | 44 | 11 | 69 | 23 | 8 |
| g.6537A>T (p.M229L) | rs2270565 | 89 | 11 | 0 | 87 | 13 | 0 |
1New variants; 2More frequent polymorphism in obese patients (P = .002) than in controls. wt: wild-type homozygous subjects; HE: heterozygous and HO: homozygous subjects at level of the detected variant.