Table 2.
Quantification of the protein expression of specific insulin receptor-related signaling mediators in soleus muscles of fructose-fed rats receiving 14-day treatment with myricetin or myricetin plus MOR antagonist.
| Relative units | Fructose-fed rats | ||
|---|---|---|---|
| Vehicle | Myricetin | Myricetin + β-FNA | |
| IR | 1.00 ± 0.07 | 1.04 ± 0.06 | 0.99 ± 0.05 |
| IRS-1 | 1.01 ± 0.06 | 1.18 ± 0.05a | 1.02 ± 0.08 |
| p85 | 1.01 ± 0.05 | 1.21 ± 0.07a | 1.08 ± 0.04 |
| Akt | 1.00 ± 0.08 | 1.15 ± 0.06a | 0.96 ± 0.09 |
| AS160 | 1.01 ± 0.07 | 1.17 ± 0.04a | 1.03 ± 0.06 |
Fructose-fed rats received i.v. injection of myricetin (1 mg kg−1), thrice daily for 14 days. β-FNA (10 μg kg−1) was i.v. injected 30 min prior to administration of myricetin. The vehicle used to dissolve the tested drugs was given at the same volume. Values (mean ± SEM) were obtained from 5 rats. a P < .05 represents the level of significance compared to the values of the vehicle-treated group.