Fig. 3.

Concentration of sites from the dominant epitopes presented by elite controllers in each sector and comparison of mutation patterns in sectors 1 and 3 in viruses derived from elite controllers. (A) Epitope is defined as dominant if it is the most targeted (in Gag) by individuals with the corresponding HLA allele. Concentration is the number of epitope sites in the sector divided by the total number of residues in the sector. The P value of association with each sector is in SI Appendix 10. Only sector 3 is significantly enriched with sites from the dominant epitopes of HLA molecules associated with control. Sectors 4 and 5 are not targeted at multiple points because they contain only 10 and 14 sites, respectively. Sectors 1 and 3 are targeted at multiple points. (B) Comparison of the number of unique viral strains obtained from a cohort of elite controllers that contains different numbers of mutations in sectors 1 and 3.